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OCR: wth and These patients have a slow tempo of gr cal maturation, and all aspects of their phys onsidered development are delayed. They may be pulse to have a functional defect of the GnRH generator. In such children adrenarche his characteristically late, as is gonadarche. 1 adotrophin contrasts with patients with isolated gor occurs at a deficiency, in whom adrenarche usually normal age